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Genomyx CREignite (30 Servings)

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Genomyx CREignite (30 Servings)


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Genomyx CREignite: The Evolution of Creatine Supplementation!

**DELICIOUS Watermelon Flavor!**

Getting into the creatine market we didn’t want to just pump out your same generic blends with the same generic ingredients. Most blends rarely seem to deliver much more than regular old creatine but we wanted to deliver a blend to our Fanatyx that would restore their faith in this particular category. Creatine blends have a lot of potential and if you give us a shot we’re going to show you just how far they can take your performance.

Creatine Monohydrate:

Regardless of your particular sport you’ve likely already heard of creatine at some point. It’s the one supplement everyone seems to know but unfortunately few seem to have a solid of understanding of what it is and what it does. Its benefits to exercise performance has been so deeply researched and so greatly supported by the athletic community that to not use it would be crazy.

A quick summary for those less experienced with creatine: Creatine monohydrate functions by increasing intracellular creatine stores (1). Creatine phosphate is a key member in the production of ATP, which is one of the main forms of energy utilized in the body. During intense exercise as ATP becomes used and converted to ADP creatine phosphate can donate its phosphate group returning it to ATP to be reutilized(5). The effect is most strongly pronounced during short bouts of power such as sprinting, weight lifting, or various other high impact sports.

The impact of creatine on cell volume is more important than most tend to understand. A larger cell has more surface area and optimizes cellular life, and greatly improves cellular functions like glycogen uptake (2). Increased glycogen uptake to skeletal muscle is preferential for any athlete as it will undoubtedly lead to enhanced performance. In addition, the increased cell volume and creatine stores promote greater performance and training adaptations, effectively enhancing every workout (3).

Creatine Monohydrate Overview:

  • Increases in cell volume (1)
  • Increases in fat free mass (4)
  • Improves exercise performance (3)
  • Increase in skeletal muscle glycogen uptake capacity(2)
  • Improve recovery time(5)

Magnesium Creatine Chelate:

Why two different sources of creatine, wouldn’t they all have the same effect? The answer is a confusing yes and no. Creatine Monohydrate is a nice cheap source of creatine that delivers the results as promised of creatine. However many people can find GI distress with higher doses of creatine monohydrate and to get creatines effects you need to make sure you’re dosing enough to saturate creatine phosphate stores. The effect takes time and results will be subtle to non-existent in non responders or people dosing too little.

This is where Magnesium Creatine Chelate, more commonly referenced as MCC, comes in to play. Anecdotal reports suggest MCC doesn’t produce the same GI distress more commonly noticed with creatine monohydrate. MCC also appears to be a superior creatine form in regards to overall effects.

A study was done comparing magnesium creatine chelate supplementation to magnesium oxide and creatine supplementation. Both protocols produced similar significant increases in power compared to placebo with significant increases in peak torque and great increases in work capacity from the MCC group. The magnesium creatine chelate group had some surprisingly significant effects compared to magnesium oxide and creatine supplementation group(6).

The researchers also measured the effects both groups had on water composition of the body including intracellular, extracellular and total body water retention. It was found that only the magnesium creatine chelate group had a significant increase in intracellular water retention and significant decrease in extracellular water retention and researchers attributed this to a better uptake of creatine(6).

This is the volumizing effect of the cell we are looking for with creatine that will also produce significant improves in how your physique looks as muscle bellies expand with water. Beyond the effects of the creatine, MCC also supplies a significant amount of magnesium. Magnesium is important for a host of biological functions including energy production and exercise has the potential to reduce magnesium status in athletes(7). ATP production from myokinase and creatine kinase reactions require magnesium(6). However few studies have produced the favorable direct results on exercise performance that are sought with solely magnesium supplementation. Regardless it is an important mineral and from an overall health perspective it’s nice to know MCC is helping to maintain optimal magnesium status.

Magnesium Creatine Chelate Overview:

  • Improvements in exercise performance greater than that of general creatine monohydrate supplementation
  • Greater increases in intracellular body water
  • Helps maintain optimal magnesium status

Let’s not forget it should also add to all the effects of general creatine monohydrate supplementation with enhancements in a few areas. Why use both? We wanted a cost effective creatine that gave an extra kick you’re looking for with Genomyx.

Orotic Acid

This lesser known compound has a variety of benefits to enhancing exercise performance but most commonly referenced are its various impacts on ATP pools. ATP (adenosine- triphosphate ) is an important substrate in energy utilization in humans and other animals and is rapidly depleted by intense exercise (8).

Orotic acid enhances ATP pools through varying mechanisms, but more commonly noted are its ability to increase levels of the nucleosides uridine and cytidine. Uridine is capable of increasing myocardial ATP through anaerobic glycolysis (9). Through abilities to increase hepatic release pyrimidine nucleosides, orotic acid can be cardio-protective by preventing the depletion of adenine nucleotides in infarcted hearts (10).  Increases in uridine should also correlate to increases in muscular uptake of glucose, glycolysis, and myocardial performance under normal and hypoxic conditions (13).

More simply put, orotic acid has the potential to increase ATP pools under stressful conditions such as exercise and can enhance performance.

Another plausible mechanism for orotic acid’s benefits to exercise is its ability to increase the formation of beta-alanine (11). Beta-alanine is well known for its benefits to increase muscular carnosine stores and boost athletic performance during endurance exercise (12).

Orotic Acid Review:

  • Increases ATP pools
  • Cardioprotective
  • Enhances muscular glycogen stores through increased uptake
  • Increases beta-alanine formation

Astragalus Membranaceus

From here on out we’ll just refer to this herb as Astra. It’s one of the 50 fundamental herbs of traditional Chinese medicine and has many promising effects on the body for athletes its absurd.

It is studied widely for its immune system strengthening qualities which is an area where athletes can suppress their own abilities to fight of illness (14). Astra has been studied in many rodent models to show it can help promote immune function (15) but it’s also proved its worth in bigger trials. In an open clinical trial 115 patients with leukopenia received either a high dose or low dose Astra preparation. Leukopenia is a disease in which an individual has a low white blood cell count leaving them more vulnerable to infection. In both dosing groups Astra significantly elevated white blood cell count substantially boosting their immune function(16).

Healthy in more ways than one Astra is also excellent for cellular and mitochondrial health. Mitochondrial health specifically is a key factor for health and longevity and athletes who train strenuously may overwhelm their own bodies mechanisms for protecting them(17). Lipid peroxidation being a key damaging factor to the mitochondrial membrane fluidity(18) can be greatly inhibited by Astra(20). The heart is especially vulnerable to this damaging process making Astra an excellent add to any individual looking to not only build a better physique but a healthier one as well(19).

It makes us healthier, cool but how much is that really going to do for me? Fret not Fanatyx because Astra’s been field tested as well for actual performance enhancing qualities and looking at the science it’s going to do a lot for you. Animal models have shown Astra to significantly reduce symptoms of lethargy and weakness in chronically fatiguing trials where the animals were over worked and underfed (21). This is a situation not that unfamiliar with athletes who can be overzealous with their training and often go too far to recover. For this reason competitive body builders and physique athletes will greatly appreciate what Astra does for them as they train for many weeks on hypocaloric diets to get into peak condition for competitions.

Will I notice that in the gym, what if I’m eating plenty and go to bed on time, will it really do much? Actually yes, Astra has been shown in animal models using rodents and forced swimming trials that it can significantly extend swimming time and enhance endurance capacity(22). It also slows blood lactate accumulation and reduces serum BUN levels post exercise. Elevated BUN(blood urea nitrogen) levels can cause symptoms of lethargy so using Astra can reduce that post workout fatigue you might be accustomed to. It’s shown to be cardio protective in vivo in rodent models through its antioxidative and nitric oxide inducing properties(23).

Astragalus Membranaceus Review:

  • Protective of athletes immune function
  • Protective of cellular and mitochondrial health
  • Cardioprotective
  • Fights chronic fatigue symptoms
  • Enhances endurance capacity
  • Positively modulates BUN levels after exercise

CREignite Overview:

Now you can see how this isn’t your generic run of the mill creatine blend, it’s going to impact multiple areas of your training abilities. With creignite you’ll see PR’s not only on your one rep max but also great increases in athletic performance and endurance capacity over all. It’s a creatine blend taken to the next level so we can give any athlete that edge their looking for.

Creignite Total Mechanism of Action:

  • Increases ATP pools enhancing performance capacity
  • Cardioprotective
  • Enhances muscular glycogen stores through increased uptake
  • Increases beta-alanine formation
  • Protective of athletes immune function
  • Protective of cellular and mitochondrial health
  • Fights chronic fatigue symptoms
  • Enhances endurance capacity
  • Positively modulates BUN levels after exercise
  • Increases in cell volume
  • Increases in fat free mass
  • Improves exercise performance
  • Increase in skeletal muscle glycogen uptake capacity
  • Improve recovery time
  • Improvements in exercise performance greater than that of general creatine monohydrate supplementation
  • Greater increases in intracellular body water
  • Helps maintain optimal magnesium status

CREignite Supplement Facts

Serving Size: 2 Scoops (9.167 g per scoop)
Servings per Container: 30

 
 Amount Per Serving% Daily Value
Magnesium Creatine Chelate (Supplying 2,500mg of Creatine/217mg of Magnesium) 2,717 mg **
Creatine Monohydrate 1,500 mg **
Astragalus Membranaceus (Root 4:1 Extract) 1,000 mg **
Orotic Acid 500 mg **
 

* Percent Daily Values are based on a 2000 calorie diet.
** Percent Daily Values not established.

OTHER INGREDIENTS:  Citric Acid, N&A Flavor, Sucralose, Silicon Dioxide, Red #40

CREignite Directions:

Consume one (1) to two (2) level scoop(s) in 8 oz of cold water, 30-60 minutes prior to training. And, consume another one (1) to two (2) level scoop(s) at anytime on your non-traning days. There is no need to "load" CREignite, nor take more than 1 full serving in a 24 hour period.

CREignite WARNING:

Consult a physician or licensed qualified health care professional before using this product if you have or have a family history of heart disease, angina, arrhythmia, high blood pressure, or other cardiovascular disease. Do not use if pregnant, or nursing. Athletes, check this product with your testing organization before using. User assumes all risks and liabilities related to the use of this product. If you are governed by any athletic or governing body, make sure to contact that body to ensure the use of this product is not in violation of their rules and regulations. Not for use by individuals under the age of 18. Keep out of reach of children.

References:

1. Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement
creatine monohydrate. Pharmacol Rev. 2001 Jun;53(2):161-76. Review. PubMed PMID: 
11356982.

2. Nelson AG, Arnall DA, Kokkonen J, Day R, Evans J. Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sports Exerc. 2001 Jul;33(7):1096-100. PubMed PMID: 11445755.

3. Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplementation enhances
high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab. 2000 Dec;10(4):452-63. PubMed PMID: 11099372.

4. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc. 2000 Feb;32(2):291-6. PubMed PMID: 10694109.

5. Clark JF. Creatine and phosphocreatine: a review of their use in exercise and sport. J Athl Train. 1997 Jan;32(1):45-51. PubMed PMID: 16558432; PubMed Central PMCID: PMC1319235.

6. Brilla LR, Giroux MS, Taylor A, Knutzen KM. Magnesium-creatine supplementation
effects on body water. Metabolism. 2003 Sep;52(9):1136-40. PubMed PMID: 14506619.

7. Bohl CH, Volpe SL. Magnesium and exercise. Crit Rev Food Sci Nutr. 2002;42(6):533-63. Review. PubMed PMID: 12487419.

8. Taylor DJ, Styles P, Matthews PM, Arnold DA, Gadian DG, Bore P, Radda GK. Energetics of human muscle: exercise-induced ATP depletion. Magn Reson Med. 1986 Feb;3(1):44-54. PubMed PMID: 3959889

9. Rosenfeldt FL, Richards SM, Lin Z, Pepe S, Conyers RA. Mechanism of cardioprotective effect of orotic acid. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:159-70. PubMed PMID: 9794090.

10. Richards SM, Conyers RA, Fisher JL, Rosenfeldt FL. Cardioprotection by orotic acid: metabolism and mechanism of action. J Mol Cell Cardiol. 1997 Dec;29(12):3239-50. PubMed PMID: 9441830.

11. Aonuma S, Hama T, Tamaki N, Okumura H. Orotate as a beta-alanine donor for anserine and carnosine biosynthesis, and effects of actinomycin D and azauracil on their pathway. J Biochem. 1969 Aug;66(2):123-32. PubMed PMID: 5394595.

12. Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012 Jul;43(1):25-37. Epub 2012 Jan 24. PubMed PMID: 22270875; PubMed Central PMCID: PMC3374095.

13. Kypson J, Hait G, Mathew R. Effects of uridine on the performance and the metabolism of oxygenated and hypoxic rabbit hearts. J Mol Cell Cardiol. 1978 Jun;10(6):545-65. PubMed PMID: 211239.

14. Mackinnon LT. Chronic exercise training effects on immune function. Med Sci Sports Exerc. 2000 Jul;32(7 Suppl):S369-76. Review. PubMed PMID: 10910293.

15. Jiao Y, Wen J, Yu X. [Influence of flavonoid of Astragalus membranaceus's stem and leaves on the function of cell mediated immunity in mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Jun;19(6):356-8. Chinese. PubMed PMID: 11783202.

16. Weng XS. [Treatment of leucopenia with pure Astragalus preparation—an analysis of 115 leucopenic cases]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Aug;15(8):462-4. Chinese. PubMed PMID: 8580691.

17. Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Della Valle G. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness. 1997 Dec;37(4):235-9. PubMed PMID: 9509820.

18. Chen JJ, Yu BP. Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radic Biol Med. 1994 Nov;17(5):411-8. PubMed PMID:7835747.

19. Anderson EJ, Katunga LA, Willis MS. Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart. Clin Exp Pharmacol Physiol. 2012 Feb;39(2):179-93. doi: 10.1111/j.1440-1681.2011.05641.x. Review. PubMed PMID: 22066679.

20. Hong CY, Lo YC, Tan FC, Wei YH, Chen CF. Astragalus membranaceus and Polygonum
multiflorum protect rat heart mitochondria against lipid peroxidation. Am J Chin 
Med. 1994;22(1):63-70. PubMed PMID: 8030620.

21. Kuo YH, Tsai WJ, Loke SH, Wu TS, Chiou WF. Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. J Ethnopharmacol. 2009 Feb 25;122(1):28-34. Epub 2008 Dec 6. PubMed PMID: 19103273.

22. Sun H, Wang ZB (2010). Effects on exercise endurance capacity and antioxidant properties of astragalus membranaceus polysaccharides (APS). J. Med. Plants Res., 4: 982-986

23. Zhang WD, Chen H, Zhang C, Liu RH, Li HL, Chen HZ. Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Med. 2006 Jan;72(1):4-8. PubMed PMID: 16450288.

24. van der Merwe J, Brooks NE, Myburgh KH. Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. Clin J Sport Med. 2009 Sep;19(5):399-404. doi: 10.1097/JSM.0b013e3181b8b52f. PubMed PMID: 19741313.

25. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc. 1999 Aug;31(8):1108-10. PubMed PMID: 10449011.

26. Schilling BK, Stone MH, Utter A, Kearney JT, Johnson M, Coglianese R, Smith L, O'Bryant HS, Fry AC, Starks M, Keith R, Stone ME. Creatine supplementation and health variables: a retrospective study. Med Sci Sports Exerc. 2001 Feb;33(2):183-8. PubMed PMID: 11224803.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

 

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